Manchester United's defensive woes have worsened with Tyler Blackett now suspended and Jonny Evans and Chris Smalling sidelined.
Marcos Rojo and Daley Blind may both be forced to play at centre-back with a potential debut for Luke Shaw on the left.
The front line should remain unchanged, with Juan Mata again the man to miss out in Van Gaal's adopted diamond midfield.
West Ham
Cheikhou Kouyate looks set for a prolonged spell on the sidelines, which is a real blow for the Hammers having made an impressive start to his time at the club.
The summer signing's absence could see Stewart Downing forced back into a midfield three once more, with Mauro Zarate returning to the starting line-up.
Allardyce may well persist with the midfield diamond after the success against Liverpool last time out and of Leicester's use of the system against United last weekend.
Match Facts
Man Utd have been winning at both half time and full time in their last 7 home matches against West Ham in all competitions. Man Utd win/win 1.95
Man Utd have won their last 7 home matches against West Ham in all competitions.
Man Utd win 1.40
There have been over 2.5 goals scored in 8 of Man Utd's last 9 home games in the Premier League.
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